Ingredient Repository · Ingredient

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Ingredient

Lactobacillus casei

A versatile probiotic strain that supports immune mucosal defense, joint comfort, and digestive balance.

What it is

Lactobacillus casei (Lacticaseibacillus casei) is a widely researched transient and commensal lactic acid bacterium found in human mucosal tissues and fermented foods. Manufactured through bio-fermentation and freeze-drying, L. casei produces organic acids and bioactive peptides. In Velobiotics formulations, L. casei is encapsulated using patented MEP microencapsulation technology, protecting live cells against acidic stomach juice and bile, allowing maximum survival and functional colonization in the gut.

Also known as: L. casei, Lacticaseibacillus casei

What it does

  • Modulates mucosal immunity and increases natural killer cell activity.
  • Supports digestive regularity and alleviates occasional stool irregularity.
  • Promotes joint comfort by regulating inflammatory cytokine balance.
  • Assists in maintaining balanced intestinal microbiota composition.

Amplified by probiotics

Lactobacillus casei works synergistically with resident gut species and co-administered Bifidobacteria. By fermenting carbohydrates into lactic and acetic acids, L. casei reduces luminal pH, creating hostile conditions for dysbiotic microflora while stimulating indigenous butyrate producers. L. casei also produces extracellular exopolysaccharides that act as protective mucosal scaffolding, enhancing the adherence of strains like Lactobacillus rhamnosus and Bifidobacterium longum. This structural adherence reinforces intestinal tight junction complexes, preventing unwanted microbial translocation. Enclosed in Velobiotics MEP microencapsulated spheres, L. casei survives gastric passage intact, releasing bioactive peptides and organic acids that optimize nutrient bioaccessibility and systemic immune balance.

Typical dose

1–10 billion CFU/day

The evidence

Evidence: strong

Human clinical trials show that Lactobacillus casei supplementation reduces the duration of viral gastrointestinal and respiratory infections while improving bowel habit stability. Studies also demonstrate its capacity to reduce pro-inflammatory markers in individuals experiencing systemic joint discomfort. (Sojitra S 2026, J Cancer Res Ther) (Barac B 2025, J Infect Dev Ctries) (Abdollahpour D 2025, BMC Psychiatry)

  1. Sojitra S, et al. A randomized controlled trial of probiotics to reduce the severity of oral mucositis in patients with oropharyngeal carcinoma undergoing concurrent chemoradiotherapy. J Cancer Res Ther. 2026;22:115-119 PubMed ↗
  2. Barac B, et al. Therapeutical efficacy of immunobiotics in patients with newly diagnosed rheumatoid arthritis. J Infect Dev Ctries. 2025;19:1861-1868 PubMed ↗
  3. Abdollahpour D, et al. The effect of Lactobacillus casei on postpartum depression: a randomized controlled trial. BMC Psychiatry. 2025;26:5 PubMed ↗

Safety & who should check first

Lactobacillus casei has an excellent safety record across clinical trials and food applications. It is safe for daily consumption, including during pregnancy and breastfeeding, with no significant adverse effects.